施万细胞移植治疗脊髓损伤的研究进展
钱隆1
张小雷1
黄亮节2
刘彦3
唐家广3
1.锦州医科大学解放军总医院第一附属医院研究生培养基地, 北京,1000482.第四军医大学西京医院骨科, 西安,7100323.解放军总医院第一附属医院骨科、北京市骨科植入医疗器械工程技术研究中心, 北京,100048
摘要：The incidence of spinal cord injury is very high, which often brings disastrous consequences to the patients and their families. And there is no ideal treatment. In recent years, with the in-depth study on molecular biology and genetic engineering technology, cell transplantation as the biotherapy strategy and treatment for spinal cord injury has been developed. Schwann cells have become the focus of research because of their obvious advantages for nerve repair. Schwann cells are easy to obtain and culture, and can reduce the immune rejection after autologous transplantation, which lead to no ethical restrictions. Schwann cells transplanted into the damaged spinal cord can swallow necrotic tissues, reduce tissue defects and secrete neurotrophic factors, adhesion molecules and extracellular matrices, which can promote the growth of axons and myelins, and further improve the sensory and motor function. However, due to the bad local micro environment, the promotion of axonal growth and remyelination is limited by the transplantation of only Schwann cells into the spinal cord. Therefore, the researchers have used Schwann cells with other cells / molecules and the technological transformation of genetic engineering has been realized. And furthermore, a rapid development has been achieved in the treatment of spinal cord injury, as well as the clinical application of Schwann cells. This review made a summary on the research of Schwann cell transplantation.
关键词：施万细胞细胞移植脊髓损伤干细胞遗传工程
分类号：R683.2(骨科学（运动系疾病、矫形外科学）)Q254(细胞生理学)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 357-361 )
英文信息