甲基丙烯酰胺基明胶水凝胶在关节软骨损伤修复领域中的研究进展
张传昕
李梁
吴海山
1.第二军医大学附属长征医院关节外科, 上海,2000032.第二军医大学附属长征医院关节外科, 上海,2000033.第二军医大学附属长征医院关节外科, 上海,200003
摘要：Tissue engineering has made promising progresses in the aspect of cartilage repair in nearly two decades. The use of hydrogel-based scaffolds not only promotes the extracellular environment for 3D cell culture, but also provides suitable mechanical properties. Among all kinds of hydrogels, gelatin methacryloyl hydrogels ( GelMA ) have gained great interest due to their appropriate biological properties and tunable physicochemical characteristics. This photocrosslinkable hydrogels can crosslink to form networks with tunable mechanical properties when exposed to UV light. GelMA highly mimics extracellular matrix ( ECM ) so that they can facilitate cell-attaching and retain metalloproteinase responsive peptide motifs. These characteristics allow chondrocytes to proliferate and spread in hydrogels, and contribute to self-degradation. Hybrid hydrogels can be fabricated by mixing GelMA with other polymers combineing biocompatibility and mechanical strength. GelMA plays a critical pioneering role in the field of articular cartilage repair and has promising prospects in clinical applications.
关键词：组织工程软骨关节细胞培养技术水凝胶类损伤甲基丙烯酰胺基明胶水凝胶
分类号：R681.3(骨科学（运动系疾病、矫形外科学）)R318(医用一般科学)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 633-637 )
英文信息