不明原发灶骨转移癌的诊疗进展
王达
胡劲博
刘玉杰
何韶辉
龚海熠
张浩
肖建如
1.第二军医大学附属长征医院骨肿瘤科, 上海,2000032.第二军医大学附属长征医院骨肿瘤科, 上海,2000033.第二军医大学附属长征医院骨肿瘤科, 上海,2000034.第二军医大学附属长征医院骨肿瘤科, 上海,2000035.第二军医大学附属长征医院骨肿瘤科, 上海,2000036.第二军医大学附属长征医院骨肿瘤科, 上海,2000037.第二军医大学附属长征医院骨肿瘤科, 上海,200003
摘要：Objective Bone metastasis from cancer of unknown primary ( BMCUP ) is one of the most common types among cancers of unknown primary ( CUP ), which is a heterogeneous group of cancers, and the anatomical site of origin remains occult after detailed investigations of medical history, physical examinations and related laboratory tests. Due to its insidious onset, non-specific symptoms, high risk of involving multiple organs as well as poor prognosis, early diagnosis is rather difficult. This article will make a brief review of related literatures and aim at presenting current diagnostic and therapeutic strategies of BMCUP. Methods By using key words such as bone metastases, cancer of unknown primary, immunohistochemistry, molecular diagnosis and targeted therapy, we searched databases including Pubmed, EMBASE, Web of Science and CNKI. Results Lung cancer was the main causative occult primary for bone metastases and had a poor prognosis with an average survival of 3 months. Diagnostic approaches to identify the primary sites included clinical evaluation, detailed radiological assessment and histopathological examination. The main purpose of current diagnosis was to identify the primary sites of BMCUP and make a classification according to their prognosis. Clinical protocols focused on direct and effective treatment of subtypes with good prognosis, as well as long-term and effective control of subtypes with poor prognosis. With the rapid development of molecular biology and genomics, molecular diagnosis may be the cornerstone of the future treatment of BMCUP. Conclusions Compared to treatment for bone metastases of known origin, standard treatment for BMCUP is still controversial. In the era of tailored therapeutic strategies, this situation presents both an opportunity and a challenge.
关键词：骨肿瘤肿瘤转移肿瘤未知原发灶诊断临床方案综述
分类号：R738.1(运动系肿瘤)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 716-720 )
英文信息