胫腓骨大块骨溶解症一例报告
陈金泉1
张世权2
关弘3
朱智祥2
李伟2
谭纪锋2
1.518035 深圳市第二人民医院、深圳大学医学院第一附属医院骨肿瘤中心;511436 广州医科大学研究生院2.518035,深圳市第二人民医院、深圳大学医学院第一附属医院骨肿瘤中心3.518035,深圳市第二人民医院、深圳大学医学院第一附属医院病理科
摘要：Objective Massive osteolysis is a rare disease characterized by progressive resorption of bones. This study aims to investigate the diagnosis and treatment of massive osteolysis, and to provide references for clinical diagnosis and therapy. Methods A typical case was reported. Etiology, clinical manifestations, imaging performance, pathology, diagnosis as well as therapy were summarized. Results Before the surgery, this patient was treated with diphosphate, calcium and vitamin D until osteolysis stopped and ossification occurred. No recurrence was observed 5 years postoperatively. Conclusions The etiology of massive osteolysis remains obscure. Traumatic history before its onset may be of significance. Massive osteolysis is characterized by an aggressive bone dissolution, whose clinical manifestations are non-specific. Malignancy signs appear in CT or MRI images, which may lead to missed diagnosis or misdiagnosis because of its contradictions to clinical manifestations and pathology. MRI enhanced imaging helps to identify. Multiple biopsies and sufficient sample size are beneficial for accurate pathologic diagnosis. The diagnosis of massive osteolysis need to combine clinical imaging results and pathology data. There are no effective methods in the treatment of massive osteolysis at present. Treatment principles mainly include the inhibition of bone resorption, prevention and control of complications. It is suggested that the combination of zoledronic acid, calcium and vitamin D can be applied to inhibit the bone dissolution. Surgery should be determined by limb functions. A multi-center clinical study on massive osteolysis is expected to further refine treatment strategies.
关键词：胫骨腓骨骨质溶解二磷酸盐类钙维生素D病例报告
分类号：R681(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 236-239 )
英文信息