microRNA在破骨细胞分化和功能中扮演的角色
谢保平
李劲平
石丽颖
1.中南大学湘雅药学院, 湖南,4100002.中南大学湘雅药学院, 湖南,4100003.中南大学湘雅药学院, 湖南,410000
摘要：Osteoclasts are multi-nucleated giant cells derived from hematopoietic stem cell precursors, playing a unique role in bone resorption. Osteoclast activity is associated with osteoporosis, osteosclerosis, bone injury and other diseases. Its differentiation is regulated by many factors. It has been found that miRNA acts on the targets of osteoclast differentiation, which regulates the differentiation process and bone resorption functions in recent years. This article focuses on the role of miRNAs in osteoclast-related receptor signaling pathways and provides references to explore effects of miRNA in osteoclast differentiation.
关键词：破骨细胞信号传导微小RNA综述
分类号：R681(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(81273816)国家自然科学基金(81774379)湖南省自然科学基金(2017JJ2338)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 364-368 )
英文信息