TLR4通路与激素性股骨头坏死关系的研究进展
朱道宇
杨前昊
高悠水
张长青
1.上海交通大学附属第六人民医院骨科, 2002332.上海交通大学附属第六人民医院骨科, 2002333.上海交通大学附属第六人民医院骨科, 2002334.上海交通大学附属第六人民医院骨科, 200233
摘要：Osteonecrosis of the femoral head (ONFH) is a leading cause of hip diseases in young adults and is frequently observed in patients treated with high dose of glucocorticoids.There have been various hypotheses about the pathogenesis of glucocorticoid-induced ONFH.Studies have shown that inflammation and inflammatory cytokines play a crucial role in many diseases and are also an important contributors in the glucocorticoid-induced ONFH.TLR4, a major member of Toll-like receptor family, is the most important pattern recognition receptor for endotoxin/lipopolysaccharide.It is a pivotal mediating factor in the development of glucocorticoid-induced ONFH.Studies showed that glucocorticoids could induce excessive activation of Myd88-dependent TLR4 signaling pathway with NF-κB transferred into nuclear and the release of inflammatory cytokines, such as TNF-α, IL-1βand IL-6.NF-κB could exert both promotion and inhibition effects on the osteogenic differentiation and calcium deposition of osteoblasts, promote bone resorption, destroy bone homeostasis and inhibit angiogenesis.A variety of inflammatory cytokines also have significant effects on the destruction, resorption and regeneration of the bone.Eventually it could lead to ONFH.The research on TLR4 signaling pathway could not only reveal the pathogenesis of glucocorticoid-induced ONFH, but also provide references for the prevention and treatment of ONFH.It is of great significance for the early treatment of glucocorticoid-induced ONFH and incidence reduction.
关键词：Toll样受体股骨头坏死综述
分类号：R681(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(81672143)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 75-79 )
英文信息