地塞米松及氨甲环酸在全髋全膝关节置换术中抗炎作用的研究进展
许宏
谢锦伟
雷一霆
陈果
裴福兴
1.610041 成都，四川大学华西临床医学院华西医院骨科2.610041 成都，四川大学华西临床医学院华西医院骨科3.610041 成都，四川大学华西临床医学院华西医院骨科4.610041 成都，四川大学华西临床医学院华西医院骨科5.610041 成都，四川大学华西临床医学院华西医院骨科
摘要：Total hip/knee arthroplasty is an orthopedic surgery with significant fibrinolysis and inflammatory system activation. However, the perioperative use of tranexamic acid (TXA)，a synthetic lysine derivative, in total joint arthroplasty (TJA) greatly reduced the total blood loss and decreased the transfusion rate without increasing the risk of thromboembolic complications. Traditional dexamethasone was used to inhibit perioperative inflammations. Several studies in recent years have shown that TXA can not only inhibit fibrinolytic reactions after TJA, but also have obvious anti-inflammatory effects. The aim of this review is to discuss the relationship between flbrinolysis and inflammatory system, the latest progress, potential problems and orientation of future research on the anti-inflammatory effects of dexamethasone and TXA in TJA.
关键词：氨甲环酸地塞米松关节成形术置换膝髋综述
分类号：R687.4(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2020-06-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 439-444 )
英文信息