铁死亡对骨肉瘤进展作用影响的研究
章磊
黎承军
解瑞
崔恩宁
210000 江苏省,南京医科大学附属金陵医院骨科
摘要：Osteosarcoma is a kind of malignant bone tumor originating from primitive osteoblastic mesenchymal cells,which is prone to relapse and distant metastasis in children and adolescents.In the past 30 years,systematic and standardized treatment of osteosarcoma has been developed,including neoadjuvant chemotherapy,surgery and postoperative chemoradiotherapy.However,due to the limitations of traditional treatment and tumor heterogeneity,the five-year survival rate of osteosarcoma patients has not been substantially improved.Ferroptosis is a new modality of programmed cell death induced by ferrous ion overload and lipid peroxide accumulation.It shows great potential in inducing tumor cell death and reversing drug resistance.In order to seek a new treatment for osteosarcoma,research teams at home and abroad have made some achievements in the study of the mechanism of osteosarcoma and ferroptosis.With the development of molecular targeting and biological nanotechnology,targeted regulation of ferroptosis in tumor cells has been widely concerned by scholars.This article reviews the progress of ferroptosis mechanism in the treatment of osteosarcoma.
关键词：骨肉瘤铁死亡磷脂氢过氧化物谷胱甘肽过氧化物酶给药系统分子靶向治疗综述
分类号：R738.1(运动系肿瘤)
资助基金：中国博士后特别资助基金项目(2017T100824)中国博士后面上基金项目(2016M593039)
论文发表日期：2023-12-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 937-942 )
英文信息