骨免疫微环境中炎症因子诱导骨丢失的机制及免疫治疗研究进展
王志凌1
郭源源2
张浩3
傅德皓4
1.264003 山东省,滨州医学院烟台附属医院手足外科2.430061 湖北省,华中科技大学同济医学院附属梨园医院药剂科3.430061 湖北省,华中科技大学同济医学院附属梨园医院老年病科4.200080 上海市第六人民医院创伤骨科
摘要：Inflammation induced-bone loss is an universal phenomenon in chronic inflammatory diseases and age-related diseases.However,its mechanism is still not clear.Following the development of osteoimmunology,the effects of inflammatory cytokines in bone immune-microenvironment on osteoclasts and osteoblasts through osteoprotegerin/receptor activator of nuclear factor kappa-B(NF-κB)ligand/receptor activator of NF-κB(OPG/RANKL/RANK)pathway have been researched widely.Meanwhile,immunotherapy aiming at chronic inflammation hasbeen already applied in treating immunoporosis.This article will review the essential signaling mechanism of pro-inflammatory cytokines,including the suppression of osteoblastogenesis and promotion of osteoclastogenesis,as well as the current therapies based on cytokines and lymphocytes for inflammatory bone loss.
关键词：骨质吸收细胞因子类信号传导破骨细胞骨质疏松综述
分类号：R681(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(82370889)
论文发表日期：2023-12-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 943-948 )
英文信息