膝骨关节炎表观遗传学研究进展
徐斌丰1
宋月莹1
吴海君1
郑程2
1.311400 浙江省,杭州市富阳区鹿山街道社区卫生服务中心医疗康复科2.310051 杭州,浙江康复医疗中心骨伤康复科
摘要：Knee osteoarthritis is a complex genetic joint disease,and epigenetic factors play an important role in its development.The mechanisms of epigenetic regulation mainly include DNA modification,histone posttranslational modifications and non-coding RNA regulation.Epigenetic traits are cell-and tissue-specific and can vary with the environment.Unraveling of their roles in human tissues are particularly difficult.As the lowered threshold for gene sequencing,some epigenomic studies have summarized and improved epigenetic models and elucidated the mechanisms of the actions between epigenetic factors and knee osteoarthritis,which could help to understand the disease and develop new epigenetic-based therapeutic targets.This review reviews the progress of epigenetics in knee osteoarthritis.
关键词：骨关节炎膝表观基因组学DNA甲基化RNA未翻译组蛋白修饰综述
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2024-01-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 51-56 )
英文信息