巨噬细胞与髓核细胞相互通讯在椎间盘退变中的作用
陈湘元1
朱柏扬2
胡安钰2
林晓玲2
王丹丹3
1.250062 济南,山东第一医科大学附属颈肩腰腿痛医院,山东省骨生物力学工程实验室2.250000 济南,山东第一医科大学 (山东省医学科学院)3.250000 济南,山东第一医科大学临床与基础医学院
摘要：Intervertebral disc degeneration(IVDD)is the primary factor causing low back pain,which is characterized as a chronic disease with multiple contributing factors.The inflammation is crucial to the entire pathogenic process.Macrophages can infiltrate into the nucleus pulposus.With various factors stimulation,macrophages interact with nucleus pulposus cells through MAPK and NF-κB signaling pathways,leading to inflammatory cytokines release,cell proliferation inhibition,apoptosis of nucleus pulposus cells,and disruption of the extracellular matrix metabolic environment.Additionally,the degenerated nucleus pulposus cells cause macrophage polarization,migration,and infiltration through the corresponding cytokines.Both of these cause inflammatory interactions accelerating the development of IVDD.The present study summarizes the intercellular communication between macrophages and nucleus pulposus cells,and lays a foundation for the understanding of the molecular mechanisms of IVDD.
关键词：椎间盘退行性变巨噬细胞髓核炎症细胞通讯综述
分类号：R681.5(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2024-01-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 63-68 )
英文信息