circRNA经由ceRNA机制调控BMSCs成骨分化在股骨头坏死中的研究进展
柳可心1
刘凯1
冬梅2
王建忠3
1.010030 呼和浩特,内蒙古医科大学2.010030 呼和浩特,内蒙古医科大学第二附属医院骨质疏松科3.010030 呼和浩特,内蒙古医科大学第二附属医院创伤外科中心C区
摘要：Osteonecrosis of the femoral head(ONFH)is one of the common diseases in orthopedics.The disease has complex pathogenic factors and high disability rate,which can eventually lead to structural changes of the femoral head,collapse of the femoral head,and hip joint dysfunction.With the development of high-throughput sequencing technology,many studies have shown that circular RNA(cirRNA)can regulate the osteogenesis and differentiation of bone marrow mesenchymal stem cells(BMSCs)through competing endogenous RNA(ceRNA)mechanism,and affect the occurrence and development of ONFH.In addition,circRNA is expected to become an ONFH diagnostic biomarker and participates in ONFH precision medicine as a therapeutic target.In this review,circRNA regulates osteogenic differentiation of BMSCs through ceRNA mechanism,and we discuss the role of this process in ONFH,in order to provide a new idea for diagnosis and treatment of ONFH.
关键词：RNA环状间质干细胞股骨头坏死竞争性内源 RNA综述
分类号：R681.8(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(81860401)内蒙古自治区硕士研究生科研创新项目(S20231189Z)内蒙古医科大学大学生创新创业训练计划项目(S202310132019X)内蒙古医科大学致远人才计划(ZY110018)内蒙古自治区科技计划(2022YFSH0075)
论文发表日期：2024-03-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 219-224 )
英文信息