免疫系统在不同类型骨质疏松症的作用研究进展
李朝霞1
张晓峰1
徐西林2
刘江燕1
1.150006 哈尔滨,黑龙江中医药大学2.150036 哈尔滨,黑龙江中医药大学附属第二医院骨科
摘要：Classical theories suggest that osteoporosis is essentially a disorder of bone remodeling caused by estrogen deficiency,primary osteoporosis of aging,or secondary osteoporosis to diseases and drugs.However,in recent years,advances in the understanding of the complex link between bone and the immune system have led Srivastava et al.to introduce the new term"immunoarporosis"to describe the growing importance of immune cells in osteoporosis.In postmenopausal osteoporosis,immune cell changes mediated by estrogen deficiency stimulate osteoclast activation to varying degrees.In senile osteoporosis,aging causes persistent activation of the immune system at a low level,which disrupts the immune balance and ultimately leads to bone loss.In diabetic osteoporosis,hyperglycemia caused by insulin deficiency or resistance may lead to abnormal regulation of immune cells and excessive production of pro-inflammatory factors leading to osteoporosis.Therefore,this article reviews the relationship between immune cells and three kinds of osteoporosis,in order to provide new therapeutic targets for different osteoporosis.
关键词：免疫细胞细胞因子类骨质疏松绝经后老年人糖尿病综述
分类号：R681(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(81904222)黑龙江省重点研发计划(GZ20210)全国基层名老中医药专家传承工作室建设项目(No.2021-2024)
论文发表日期：2024-03-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 225-230 )
英文信息