椎间盘退变中外泌体的功能、作用机制和临床治疗
苗鸿雁1
冯晶2
刘伟2
杜世阳1
杨若鹏1
尹志源1
肖子钧1
徐磊1
1.430065 武汉,湖北中医药大学2.430022 湖北省,武汉市第一医院骨科
摘要：Intervertebral disc degeneration(IVDD)is the main cause of low back pain,and the prevalence rate is increasing year by year.However,the exact cause of IVDD is still unclear.Most conservative treatment and surgical treatment can not prevent the progress of IVDD or restore the original structure and function,and are often accompanied by obvious sequelae and complications.Exosomes are extracellular vesicles with a diameter of 40-160 nm,which are composed of lipid bilayers encapsulating proteins,nucleic acids,etc.,and play an important regulatory role as intercellular communication substances.By delivering a large number of bioactive substances to damaged cells,exosomes have received great attention in maintaining the stability of intervertebral disc structure and function.However,there are still some challenges in the production,application and efficacy evaluation of exosomes,which are worthy of further exploration.This article focuses on the mechanism of exosomes from different sources in regulating cell proliferation and apoptosis,endoplasmic reticulum stress,inflammation,pyroptosis,oxidative stress,autophagy,extracellular matrix stability,differentiation and angiogenesis in the process of IVDD in recent years,in order to provide thinking for subsequent in-depth research.
关键词：椎间盘退行性变外泌体综述
分类号：R681.5(骨科学（运动系疾病、矫形外科学）)
资助基金：武汉市卫生健康科研基金(WZ21C04)武汉市卫生健康科研基金(WX21M02)
论文发表日期：2024-03-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 231-236 )
英文信息