脊髓损伤后巨噬细胞脂代谢与炎症表型关系研究进展
杨真吾
彭颖
林浩东
201600 上海交通大学医学院附属第一人民医院创伤临床医学中心
摘要：After spinal cord injury(SCI),the myelin debris resulting from axonal collapse is considered as a significant impediment to nerve regeneration.The removal of myelin debris is crucial to establish a favorable microenvironment for nerve regeneration.Macrophages play a pivotal role in this clearance process.However,following phagocytosis,the lipid levels within macrophages increase significantly,leading to disrupted lipid metabolism and eventual foam cell formation.This proinflammatory type of foamy macrophage is unable to transition to the anti-inflammatory phenotype which is necessary for repair.Consequently,the lesion area remains stuck in the inflammatory phase for an extended period,hampering the post-SCI repair process.We reviewed the connection and mechanisms between lipid metabolism and inflammatory phenotype of macrophages after SCI.Furthermore,we discussed potential lipid metabolism-related genes that could facilitate repair,offering a novel strategy for SCI treatment.
关键词：脊髓损伤巨噬细胞脂代谢炎症综述
分类号：R744(神经病学与精神病学)
资助基金：上海市科技计划项目(20Y11913100)
论文发表日期：2024-04-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 290-298 )
英文信息