miR-26a对骨肉瘤发生转移及治疗作用的研究进展
李广渝
王旭东
李明
050000 石家庄,河北医科大学第二医院骨科
摘要：Osteosarcoma represents the most common form of bone malignant tumor with strong aggressiveness,easy metastasis,and chemotherapy resistance.The pathogenesis of osteosarcoma is yet to be fully elucidated.MicroRNAs are classified as noncoding small RNA with a length of 20-22 nucleotides,which are abnormally expressed in a variety of malignant tumors.miR-26a is an important member of the MicroRNA family,and its expression has been found to be associated with the occurrence,development,invasion,metastasis and drug resistance of osteosarcoma.Mechanism of miR-26a in osteosarcoma has important clinical significance for the diagnosis,treatment and prognosis of osteosarcoma.This article reviews the effects of miR-26a on the occurrence,development,invasion,metastasis and drug resistance of osteosarcoma,which provides a reference for the diagnosis and prediction of osteosarcoma.
关键词：骨肉瘤微RNA抗药性肿瘤miR-26a综述
分类号：R738.1(运动系肿瘤)
资助基金：河北省自然科学基金(H2021206321)
论文发表日期：2024-05-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 396-400 )
英文信息