外泌体来源的miRNAs在骨肿瘤发病机制中的调控作用
姚琦媛1
姚丽1
崔琳1
谢美明1
赵检1
蓝奉军2
1.610000 成都,中国人民解放军西部战区总医院2.610000 成都,四川大学华西医院骨科
摘要：Bone tumors develop within or from various components of bone tissues.The causes of these tumors are unclear,but it is believed that most of them are related to genetic variations.Exosomes are vesicle-like structures that contain various substances,including Messenger RNA(mRNA),microRNA(miRNA),long non-coding RNA(LncRNA),DNA,lipids,and proteins.They play a critical role in disease development by releasing these substances outside the cell for intercellular exchange,thereby facilitating information exchange.Research has shown that exosomal miRNAs are involved in the development of bone tumors,particularly in cell differentiation,proliferation,and apoptosis.Therefore,this review summarizes the latest research on exosomal miRNAs in bone tumors,highlighting the key regulatory roles and mechanisms of miRNAs in the pathogenesis of bone tumors,as well as their potential for therapeutic use.
关键词：骨肿瘤微小RNA外泌体综述
分类号：R738.1(运动系肿瘤)
论文发表日期：2024-11-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 955-960 )
英文信息