核因子κB信号通路在椎间盘退变中的研究进展
吴锦晨1
代继禄2
韩汶延3
左媛3
1.010000 呼和浩特,内蒙古医科大学2.012000 内蒙古自治区,乌兰察布市中心医院检验科3.010000 呼和浩特,内蒙古医科大学第二附属医院检验科
摘要：Low back pain (LBP) is one of the most common health problems,and the leading cause of LBP is intervertebral disc degeneration (IDD). Intervertebral disc degeneration is the consequence of the joint action of factors such as genetics,environment and nutrition,resulting in changes in cell phenotype,inflammatory reactions,increased cell senescence and death,imbalance in the metabolic homeostasis of the extracellular matrix,alterations in the mechanical properties of the nucleus pulposus,and damage to the annulus fibrosus and endplates,eventually developing into intervertebral disc degeneration. Current studies indicate that inflammatory responses play a significant role in intervertebral disc degeneration. A variety of factors can unleash the NF-κB signaling pathway,then accelerate the release of proinflammatory factors,the accumulation of reactive oxygen species,and the degradation of extracellular matrix,causing cellular senescence and finally intervertebral disc degeneration. This article introduces the function,expression and role of NF-κB signaling pathway in intervertebral disc degeneration.
关键词：椎间盘退行性变NF-κB髓核综述
分类号：R681.5(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2025-01-18
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 83-88 )
英文信息