正确认识长骨非典型软骨肿瘤的生物学行为指导临床实施科学诊治
徐明
于秀淳
250031 济南,中国人民解放军联勤保障部队第九六〇医院骨科
摘要：Atypical cartilaginous tumor(ACT)of long bones is a borderline neoplasm characterized by locally aggressive behavior and minimal metastatic potential.Historically classified as low-grade chondrosarcoma,the 2020 WHO redefined ACT as an intermediate tumor(ICD-O 9222/1)for appendicular lesions,emphasizing its distinct biological behavior.Current guidelines recommend to optimize diagnostic and therapeutic strategies based on imaging evaluation and individualized risk assessment.Imaging advancements,such as MRI-based protocols(e.g.,BACTIP)and radiomics aggressiveness scoring(RAS),enable non-invasive differentiation of ACT from higher-grade malignancies and guide decisions among observation,curettage with adjuvant therapy,and resection.Studies demonstrate that curettage achieves local control rates exceeding 95%while preserving limb function,with active surveillance feasible for stable lesions.Future directions involve integrating artificial intelligence and multimodal radiomics to refine risk stratification and treatment individualization.Clinicians must avoid overtreatment(e.g.,unnecessary wide resection)and undertreatment(e.g.,misdiagnosing high-grade tumors)through multidisciplinary collaboration and evidence-based protocols.
关键词：软骨瘤软骨肉瘤人工智能软骨肿瘤非典型述评
分类号：R738.3(运动系肿瘤)
论文发表日期：2025-05-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 385-387 )
英文信息