JAK/STAT通路在骨骼发育重塑中的免疫作用研究进展
徐鹏慧
张梦
周惠琼
100048 北京,中国人民解放军总医院第四医学中心风湿免疫科
摘要：The Janus kinase(JAK)-signal transducer and activator of transcription(STAT)signaling pathway is an important downstream mediator of multiple cytokines,hormones,and growth factors.The downstream mediated by JAK/STAT involves processes such as hematopoiesis,tissue repair,immune adaptation,inflammation,apoptosis,and adipogenesis.The absence or mutation of JAK/STAT components is associated with many diseases.Studies have shown that the JAK/STAT signaling pathway plays an important role in bone development,bone metabolism,and fracture healing.Among them,multiple inflammatory cytokines are involved in this process,mainly affecting normal bone remodeling by influencing the differentiation and maturation of osteoclasts and osteoblasts at intra-articular and extra-articular skeletal sites.This article systematically elaborates the role of the JAK/STAT pathway in skeletal development,homeostasis,and remodeling by summarizing the skeletal phenotypes of JAK/STAT knockout mouse models,the selective inhibition of JAK/STAT signal components,and the effects of JAK inhibitors on osteoclasts,osteoblasts,and osteocytes in inflammatory and non-inflammatory states.
关键词：Janus激酶类STAT转录因子类骨发育骨重建骨质疏松综述
分类号：R322.7(人体形态学)
论文发表日期：2026-01-19
在线出版日期：2026-03-09（本平台首次上网日期，不代表文献的发表时间）
页数：6( 81-86 )
英文信息