Advance in polyamidoamine dendrimers as gene delivery agents
YE Ling
GU Wei
Zhou Yulan
摘要： Gene therapy recently has become an important area of research as a new therapeutic method. In vivo and in vitro gene therapies require efficient delivery of genetic material into a cell and preferably high levels of expression of transferred gene. Traditionally, gene delivery systems are classified as viral vector-mediated systems and nonviral vector-mediated systems. Viral vectors, which have been demonstrated as systems with high transfection efficiency, however, are limited due to adverse effects such as immunogenicity, toxicity, limited DNA carrying capacity and mutagenesis caused by cell-infected viruses[1].
机标关键词：transfection efficiencytherapeutic methodcarrying capacityin vitro
分类号：R318.5(医用一般科学)
资助基金：北京市科技新星计划项目(954812000)北京市教委科技发展计划项目(00KJ-107)
论文发表日期：2002-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 556-559 )
英文信息