The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine*
Yongmei Yan
Wentao Fan
Li Liu
Ru Yang
Wenjia Yang
摘要：The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and lessen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke de-pression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distil ed water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining re-sults demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules in-creased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein ex-pression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expres-sion in hippocampi of rats with post-stroke depression, and exert antidepressant effects.
机标关键词：water consumptionimmunohistochemical stainingchronic unpredictable stressmiddle cerebral arterytherapeutic effectsrat model
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1765-1772 )
英文信息