Apoptosis in glioma-bearing rats after neural stem cell transplantation
Hua Li
Zhenjun Chen
Shaopeng Zhou
摘要：Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma. Inhibition of this aberrant activity could effectively hinder glioma cel proliferation and promote cell apoptosis. To investigate the mechanism of glioblastoma treatment by neural stem cel trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, C6 glioma cel s were prepared in sus-pension and then infused into the rat brain to establish a glioblastoma model. Neural stem cells isolated from fetal rats were then injected into the brain of this glioblastoma model. Results showed that Raf-1, Erk and Bcl-2 protein expression significantly increased, while Caspase-3 protein expression decreased. After transplantation of neural stem cells, Raf-1, Erk and Bcl-2 protein expression significantly decreased, while Caspase-3 protein expression significantly in-creased. Our findings indicate that transplantation of neural stem cel s may promote apoptosis of glioma cells by inhibiting Ras/Raf/Mek/Erk signaling, and thus may represent a novel treatment approach for glioblastoma.
机标关键词：protein expressionneural stem cellscell apoptosisglioma cells
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1793-1802 )
英文信息