Cell cycle-related genes p57kip2, Cdk5 and Spin in the pathogenesis of neural tube defects*
Xinjun Li
Zhong Yang
Yi Zeng
Hong Xu
Hongli Li
Yangyun Han
Xiaodong Long
Chao You
摘要：In the field of developmental neurobiology, accurate and ordered regulation of the cel cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified several genes involved in the development of neural tube defects. In this study, we established a model of developmental neural tube defects by administration of retinoic acid to pregnant rats. Gene chip hybridization analysis showed that genes related to the cel cycle and apoptosis, signal transduction, transcription and translation regulation, energy and metabolism, heat shock, and matrix and cytoskeletal proteins were al involved in the formation of developmental neural tube defects. Among these, cel cycle-related genes were predominant. Retinoic acid ment caused differential expression of three cel cycle-related genes p57kip2, Cdk5 and Spin, the expression levels of which were downregulated by retinoic acid and upregulated during normal neural tube formation. The results of this study indicate that cel cycle-related genes play an im-portant role in the formation of neural tube defects. P57kip2, Cdk5 and Spin may be critical genes in the pathogenesis of neural tube defects.
机标关键词：neural tube defectsretinoic aciddifferential expressioncytoskeletal proteinscrucial factorstube formation
资助基金：This study was supported by the Science and Technology Key Program of Sichuan Provincial Health Ministry, (No.080128)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1863-1871 )
英文信息