Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?*
Jing Ge
Jun Wang
Dan Xue
Zhengsheng Zhu
Zhenyu Chen
Xiaoqiu Li
Dongfeng Su
Juan Du
摘要：Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein ex-pressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preec-lampsia in pregnant rats.
机标关键词：glutamate receptorlipid metabolism
资助基金：This project was funded by the Military Medical Science and Technology General Project during the 12th Five-Year Plan Period, (No. CWS11J003)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1872-1880 )
英文信息