Is X-linked methyl-CpG binding protein 2 a new target for the treatment of Parkinson’s disease?***
Teng Xie
Jie Zhang
Xianhou Yuan
Jing Yang
Wei Ding
Xin Huang
Yong Wu
摘要：X-linked methyl-CpG binding protein 2 mutations can induce symptoms similar to those of Parkin-son’s disease and dopamine metabolism disorders, but the specific role of X-linked methyl-CpG binding protein 2 in the pathogenesis of Parkinson’s disease remains unknown. In the present study, we used 6-hydroxydopamine-induced human neuroblastoma cel (SH-SY5Y cel s) injury as a cel model of Parkinson’s disease. The 6-hydroxydopamine (50 μmol/L) treatment decreased protein levels for both X-linked methyl-CpG binding protein 2 and tyrosine hydroxylase in these cel s, and led to cel death. However, overexpression of X-linked methyl-CpG binding protein 2 was able to ameliorate the effects of 6-hydroxydopamine, it reduced 6-hydroxydopamine-induced apoptosis, and increased the levels of tyrosine hydroxylase in SH-SY5Y cel s. These findings suggesting that X-linked methyl-CpG binding protein 2 may be a potential therapeutic target for the treatment of Parkinson’s disease.
机标关键词：binding proteintyrosine hydroxylase
资助基金：This study was sponsored by the Ph.D. Independent Research Projects of Wuhan University, (No.201130302020017)a grant from the Science and Technology Bureau of Hubei Province, (No.2011CDB511)the National Natural Science Foundation of China, (No.81170769)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1948-1957 )
英文信息