Oxidative stress, mitochondrial damage and neurodegenerative diseases****
Chunyan Guo
Li Sun
Xueping Chen
Danshen Zhang
摘要：Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. Oxidative stress is characterized by the overproduction of reactive oxygen species, which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain, alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial defense systems. Al these changes are implicated in the development of these neurodegenerative diseases, mediating or amplifying neuronal dysfunction and triggering neurodegeneration. This paper summarizes the contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative eases and discusses strategies to modify mitochondrial dysfunction that may be attractive thera-peutic interventions for the treatment of various neurodegenerative diseases.
机标关键词：neurodegenerative diseasesoxidative stressamyotrophic lateral sclerosismitochondrial dysfunctionreactive oxygen speciesmembrane permeabilitymitochondrial DNA
资助基金：the National Natural Science Foundation of China, (No.81274005)Medical Science Research, Health Department of Hebei Province, (No.20110173,20090588)Hebei Education Department Science Foundation, (No.2007302)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 2003-2014 )
英文信息