Neuroprotective effects of rutaecarpine on cerebral ischemia reperfusion injury**
Chunlin Yan
Ji Zhang
Shu Wang
Guiping Xue
Yong Hou
摘要： Rutaecarpine, an active component of the traditional Chinese medicine Tetradium ruticarpum, has been shown to improve myocardial ischemia reperfusion injury. Because both cardiovascular and cerebrovascular diseases are forms of ischemic vascular disease, they are closely related. We hypothesized that rutaecarpine also has neuroprotective effects on cerebral ischemia reperfusion injury. A cerebral ischemia reperfusion model was established after 84, 252 and 504 μg/kg carpine were given to mice via intraperitoneal injection, daily for 7 days. Results of the step through test, 2,3,5-triphenyl tetrazolium chloride dyeing and oxidative stress indicators showed that rutae-carpine could improve learning and memory ability, neurological symptoms and reduce infarction volume and cerebral water content in mice with cerebral ischemia reperfusion injury. Rutaecarpine could significantly decrease the malondialdehyde content and increase the activities of superoxide dismutase and glutathione peroxidase in mouse brain. Therefore, rutaecarpine could improve neu-rological function fol owing injury induced by cerebral ischemia reperfusion, and the mechanism of this improvement may be associated with oxidative stress. These results verify that rutaecarpine has neuroprotective effects on cerebral ischemia reperfusion in mice.
机标关键词：cerebral ischemia reperfusionischemia reperfusion injuryneuroprotective effectsoxidative stresstraditional Chinese medicineintraperitoneal injectionglutathione peroxidasesuperoxide dismutase
资助基金：This study was financial y supported by Zhangjiakou Science and Technology Commission Foundation, (No.1021095D)the Hebei North University Foundation, (No. Q2010018)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2030-2038 )
英文信息