Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage Upregulation of neurotrophic factor expression**
Jixiang Ren
Xiangyu Zhou
Jian Wang
Jianjun Zhao
Pengguo Zhang
摘要： This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood. Rat models were intragastrical y administered 5, 10, 20 g/kg Poxue Huayu and Tianjing Bu-sui Decoction, supplemented with Hirudo, raw rhubarb, raw Pol en Typhae, gadfly, Fructrs Tricho-santhis, Radix Notoginseng, Rhizoma Acori Talarinowi , and glue of tortoise plastron, once a day, for 14 consecutive days. Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage, and intracerebral hematoma volume markedly reduced after treatment. Immunohistochemical staining revealed that brain-derived neurotrophic factor, tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the surrounding hematoma. Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma. Neurologic impairment obviously reduced. These results indicated that Poxue Huayu and Tianjing Busui De-coction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor.
机标关键词：neurotrophic factorcerebral hemorrhagetyrosine kinasegrowth factor expressiontherapeutic effectsmRNA expressionwater contentrat model
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 2039-2049 )
英文信息