Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment*
Liping Chen
Zhigao Sun
Fawei Wang
Chengyong Xu
Miao Geng
Hongyan Chen
Dongmei Duan
摘要： The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cel s against corticosterone-induced damage. SH-SY5Y cel s injured by 400μmol/L cor-ticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cel s, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cel apoptosis. Moreover, the effect of high-dose (30μg/mL) Shuyusan-containing se-rum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cel s against corticosterone-induced impairment by adjusting the expression of apoptosis-associ-ated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing se-rum has a protective effect on high-dose corticosterone-induced impairment.
机标关键词：neurotrophic factorprotective effectmRNA expressionsurvival rateChinese herb
资助基金：This project was funded by a grant from the Scientific Research Key Project of Armed Forces during the“12th Five-Year Plan”Period, (No. CWS12J129)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2060-2068 )
英文信息