DOI: 10.3969/j.issn.1673-5374.2013.22.006GuoXX,ChenJF,LuY,WuLY,WengZJ,YangL,XinYH,LinXM,LiangY,FangJQ.Ele
Electroacupuncture at He-Mu points reduces P2X 4 receptor expression in visceral hypersensitivity***
Xinxin Guo
Jifei Chen
Yuan Lu
Luyi Wu
Zhijun Weng
Ling Yang
Yuhu Xin
Xianming Lin
Yi Liang
Jianqiao Fang
摘要： Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats. Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome. Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X 4 receptor immu-reactivity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X 4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X 4 receptor immunoreactivity in the colon and spinal cord.
机标关键词：visceral hypersensitivityirritable bowel syndromespinal cordrat model
资助基金：This study was supported by the National Natural Science Foundation of China, (No.30973783)the Open Research Fund of Zhejiang First-foremost Key Subject--Acupuncture&Moxibustion, (No. ZTK2010A01)the scientific research grants of Shanghai Health Bureau, (No.2009209)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2069-2077 )
英文信息