Combined transplantation of GDAsBMP and hr-decorin in spinal cord contusion repair****○
Liang Wu
Jianjun Li
Liang Chen
Hong Zhang
Li Yuan
Stephen JA Davies
摘要： Fol owing spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astro-cytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, dou-ble-immunofluorescent histochemistry revealed that combined transplantation inhibited the early in-flammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was se-creted by transplanted cel s, protected injured axons. The combined transplantation promoted ax-onal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte prolifer-ation and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels.
机标关键词：spinal cord injuryneurotrophic factoraxonal regenerationsensory neurons
资助基金：funding from the Ministry of Finance People’s Republic of China, and China Rehabilitation Research Center Research Program grants, (No.2008-2,2008-3,2008-4,2008-5)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2236-2248 )