Autophagy and neurodegenerative disorders
Evangelia Kesidou
Roza Lagoudaki
Olga Touloumi
Kyriaki-Nefeli Poulatsidou
Constantina Simeonidou
摘要： Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracel ular mechanism that removes damaged organelles and misfolded proteins in order to maintain cel homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders.
机标关键词：neurodegenerative disordersneurodegenerative diseasesreactive oxygen speciesoxidative stresssurvival ratein order
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2275-2283 )
英文信息