Buyang Huanwu Decoction regulates neural stem cell behavior in ischemic brain*****
Baiyan Liu
Guangxian Cai
Jian Yi
Xuemei Chen
摘要：The traditional Chinese medicine Buyang Huanwu Decoction has been shown to improve the neu-rological function of patients with stroke. However, the precise mechanisms underlying its effect remain poorly understood. In this study, we established a rat model of cerebral ischemia by middle cerebral artery occlusion and intragastrical y administered 5 g/kg Buyang Huanwu Decoction, once per day, for 1, 7, 14 and 28 days after cerebral ischemia. Immunohistochemical staining revealed a number of cel s positive for the neural stem cel marker nestin in the cerebral cortex, the subven-tricular zone and the ipsilateral hippocampal dentate gyrus in rat models of cerebral ischemia. Buyang Huanwu Decoction significantly increased the number of cel s positive for 5-bromodeoxyuridine (BrdU), a cel proliferation-related marker, microtubule-associated protein-2, a marker of neuronal differentiation, and growth-associated protein 43, a marker of synaptic plasticity in the ischemic rat cerebral regions. The number of positive cel s peaked at 14 and 28 days after intragastric administration of Buyang Huanwu Decoction. These findings suggest that Buyang Huanwu Decoction can promote the proliferation and differentiation of neural stem cel s and hance synaptic plasticity in ischemic rat brain tissue.
机标关键词：cerebral ischemiatraditional Chinese medicinemiddle cerebral arterycerebral cortexdentate gyrusrat model
资助基金：This study was supported by grants from the National Nature Science Foundation of China, (No.30873355,81072939,81273989,81202694)the Foundation of Educational Commission of Hunan Province in China, (No.11C0954)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2336-2342 )