Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus***
Yale Duan
Rui Zhang
Min Zhang
Lijuan Sun
Suzhen Dong
Gang Wang
Jun Zhang
Zheng Zhao
摘要：Metformin may reduce food intake and body weight, but the anorexigenic effects of metformin are stil poorly understood. In this study, Sprague-Dawley rats were administered a single intracere-broventricular dose of metformin and compound C, in a broader attempt to investigate the regula-tory effects of metformin on food intake and to explore the possible mechanism. Results showed that central administration of metformin significantly reduced food intake and body weight gain, par-ticularly after 4 hours. A reduction of neuropeptide Y expression and induction of AMP-activated protein kinase phosphorylation in the hypothalamus were also observed 4 hours after metformin administration, which could be reversed by compound C, a commonly-used antagonist of AMP-activated protein kinase. Furthermore, metformin also improved lipid metabolism by reducing plasma low-density lipoprotein. Our findings suggest that under normal physiological conditions, central regulation of appetite by metformin is related to a decrease in neuropeptide Y gene expres-sion, and that the activation of AMP-activated protein kinase may simply be a response to the anorexigenic effect of metformin.
机标关键词：gene expressionprotein kinaseneuropeptide Ybody weightlipid metabolismweight gain
资助基金：grants from the National Natural Science Foundation of China, (No.31171019 and No.31200820)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2379-2388 )
英文信息