Propofol’s effect on the sciatic nerve Harmful or protective?
Yi Sun
Xizhe Zhang
Qi Zhou
Yong’an Wang
Yiwen Jiang
Jian Cao
摘要：Propofol can inhibit the inflammatory response and reduce the secretion and harmful effects of as-trocyte-derived proinflammatory cytokines. In this study, after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L 4-6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were al eviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration fol owing sciatic nerve injury.
机标关键词：nuclear factor kappa Bsciatic nerveproinflammatory cytokinesinflammatory responseimmune responsesnerve injuryspinal cord
资助基金：This study was financially supported by the Science and Technology Bureau of Inner Mongolia Autonomous Region, (No. Y2011024007)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 2520-2530 )
英文信息