Magnetic resonance morphometry of the loss of gray matter volume in Parkinson’s disease patients****
Jianguo Xia
Juan Wang
Weizhong Tian
Hongbin Ding
Qilin Wei
Huanxin Huang
Jun Wang
Jinli Zhao
Hongmei Gu
Lemin Tang
摘要：Voxel-based morphometry can be used to quantitatively compare structural differences and func-tional changes of gray matter in subjects. In the present study, we compared gray matter images of 32 patients with Parkinson’s disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores. Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls. In particular, the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced, but mean scores of non-motor symptoms significantly increased, in patients with Parkinson’s dis-ease. In addition, gray matter volume was significantly diminished in Parkinson’s disease patients compared with normal controls, including bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of the cerebel um. These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson's disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson’s disease.
机标关键词：magnetic resonancetemporal lobeparietal lobefrontal lobe
资助基金：the Priority Academic Program Development of Jiangsu Higher Education Institutions, the Medical Clinical Science and Technology Developemnt Fund of Jiangsu University, (No. JLY20120122)Innovative Climb Program of Natural Science Foundation of Jiangsu Province, (No. BK2008010)the Natural Science Foundation of Nantong University, (No.11Z001)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2557-2565 )