Protective effects of dl-3n-butylphthalide against diffuse brain injury**
Yaning Zhao
Jianmin Li
Pan Zhang
Changxiang Chen
Shuxing Li
摘要：Dl-3n-butylphthalide can effectively treat cerebral ischemia; however, the mechanisms underlying the effects of dl-3n-butylphthalide on microcirculation disorders fol owing diffuse brain injury remain unclear. In this study, models of diffuse brain injury were established in Sprague-Dawley rats with the vertical impact method. Dl-3n-butylphthalide at 80 and 160 mg/kg was given via intraperitoneal injection immediately after diffuse brain injury. Ultrastructural changes in the cerebral cortex were observed using electron microscopy. Cerebral blood flow was measured by laser Doppler flowmetry, vascular density was marked by tannic acid-ferric chloride staining, vascular permeability was es-timated by the Evans blue method, brain water content was measured using the dry-wet method, and rat behavior was measured by motor function and sensory function tests. At 6, 24, 48, and 72 hours after administration of dl-3n-butylphthalide, reduced cerebral ultrastructure damage, in-creased vascular density and cerebral blood flow, and improved motor and sensory functions were observed. Our findings demonstrate that dl-3n-butylphthalide may have protective effects against diffuse brain injury by ameliorating microcirculation disorder and reducing blood-brain barrier dam-age and cerebral edema.
机标关键词：brain injurycerebral blood flowvascular densitymicrocirculation disorderintraperitoneal injectionelectron microscopyprotective effectssensory functions
资助基金：This study was supported by the grants from Hebei Province Science and Technology Ministry, (No.20276102D)Key Project of Hebei Province Education Ministry, (No. ZD2010106)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2615-2624 )
英文信息