Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats*******
Yang Liu
Zhanhua Liang
Jing Liu
Wei Zou
Xiaoyan Li
Yachen Wang
Lijia An
摘要：Caveolin-1 is involved in the regulation of synaptic plasticity, but the relationship between its pression and cognitive function during aging remains controversial. To explore the relationship be-tween synaptic plasticity in the aging process and changes in learning and memory, we examined caveolin-1 expression in the hippocampus, cortex and cerebel um of rats at different ages. We also examined the relationship between the expression of caveolin-1 and synaptophysin, a marker of synaptic plasticity. Hippocampal caveolin-1 and synaptophysin expression in aged (22-24 month old) rats was significantly lower than that in young (1 month old) and adult (4 months old) rats. pression levels of both proteins were significantly greater in the cortex of aged rats than in that of young or adult rats, and levels were similar between the three age groups in the cerebel um. Linear regression analysis revealed that hippocampal expression of synaptophysin was associated with memory and learning abilities. Moreover, synaptophysin expression correlated positively with caveolin-1 expression in the hippocampus, cortex and cerebel um. These results confirm that caveolin-1 has a regulatory effect on synaptic plasticity, and suggest that the downregulation of hippocampal caveolin-1 expression causes a decrease in synaptic plasticity during physiological aging.
机标关键词：regression analysislearning and memorylearning abilitiescognitive functionaging processage groupsadult ratsaged rats
资助基金：This work was funded by the National Natural Science Foundation of China, (No.81071009,31200740,81271412)the International S&T Cooperation Project of the Ministry of S&T of China, (No.2010DFR30850)the People’s Livelihood S&T Project, the Bureau of S&T of Dalian, (No.2010E11SF008,2011E12SF030)the Doctoral Fund of S&T Department of Liaoning Province, (No.20121109)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2725-2733 )
英文信息