Global view of transcriptome in the brains of aged NR2B transgenic mice*****
Chunxia Li
Men Su
Huimin Wang
Yinghe Hu
摘要：NR2B subunits are involved in regulating aging, in particular, age-related learning and memory deficits. We examined 19-month-old NR2B transgenic mice and their littermate controls. First, we detected expression of the NR2B subunit gene, Grin2b, in the neocortex of transgenic mice using real-time PCR. Next, we used microarrays to examine differences in neocortical gene expression. Pathway and signal-net analyses identified multiple pathways altered in the transgenic mice, in-cluding the P53, Jak-STAT, Wnt, and Notch pathways, as wel as regulation of the actin cytoskeleton and neuroactive ligand-receptor interactions. Further signal-net analysis highlighted the P53 and insulin-like growth factor pathways as key regulatory pathways. Our results provide new insight into understanding the molecular mechanisms of NR2B regulated age-related memory storage, normal organismal aging and age-related disease.
机标关键词：transgenic micemolecular mechanismslearning and memorygene expressiongrowth factor
资助基金：the National Natural Science Foundation of China, (No.30800312 and 30970368)the Specialized Research Fund for the Doctoral Program of Higher Education, (No.20070269026)the Fundamental Research Fund for the Central Universities, (No.78210020)Innovation Program of Shanghai Municipal Education Commission, (No.10ZZ35)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2734-2743 )
英文信息