Valproic acid protects neurons and promotes neuronal regeneration after brachial plexus avulsion****
Qiang Li
Dianxiu Wu
Rui Li
Xiaojuan Zhu
Shusen Cui
摘要：Valproic acid has been shown to exert neuroprotective effects and promote neurite outgrowth in several peripheral nerve injury models. However, whether valproic acid can exert its beneficial effect on neurons after brachial plexus avulsion injury is currently unknown. In this study, brachial plexus root avulsion models, established in Wistar rats, were administered daily with valproic acid dis-solved in drinking water (300 mg/kg) or normal water. On days 1, 2, 3, 7, 14 and 28 after avulsion injury, tissues of the C 5-T 1 spinal cord segments of the avulsion injured side were harvested to in-vestigate the expression of Bcl-2, c-Jun and growth associated protein 43 by real-time PCR and western blot assay. Results showed that valproic acid significantly increased the expression of Bcl-2 and growth associated protein 43, and reduced the c-Jun expression after brachial plexus avulsion. Our findings indicate that valproic acid can protect neurons in the spinal cord and enhance neuronal regeneration fol owing brachial plexus root avulsion.
机标关键词：brachial plexusperipheral nerve injuryneuroprotective effectsspinal cordneurite outgrowthdrinking waterwestern blotWistar rats
资助基金：Graduated Innovation Fund of Jilin University, (No.20121115)the National Natural Science Foundation of China, (No.30872626)Key Projects of Clinical Sciences by the Ministry of Health, (No.439)the Research Fund for the Doctoral Program of Higher Education, (No.20070183143)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 2838-2848 )
英文信息