Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction
Sijie Li
Yanbo Zhang
Guo Shao
Mingfeng Yang
Jingzhong Niu
Guowei Lv
Xunming Ji
摘要：Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute ce-rebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we in-duced a photochemical model of cerebral infarction in an inbred line of mice (BALB/c). Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment. Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction, mainly in neurons and vascular endothelial cells. Hy-Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31. Moreover, hypoxic preconditioning reduced the infarct volume and improved rological function in mice. These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra, which promoted angiogenesis.
机标关键词：acute cerebral infarctionhypoxic preconditioningendothelial growth factorischemic penumbravascular endothelial cellsprotective effectinbred line
资助基金：This study was supported by the National Natural Science Foundation of China, (No.30870854)the Natural Science Foundation of Beijing, (No.7111003)the Natural Science Foundation of Shandong Province, (No. ZR2010HM029)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2895-2903 )
英文信息