Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke
Lu Hao
Liming Chen
Xiaoyong Sai
Zhefeng Liu
Guang Yang
Rongzeng Yan
Lili Wang
Caiyun Fu
Xuan Xu
Zhenzhen Cheng
Qiang Wu
Shuzhang Li
摘要：Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke. However, whether both factors exert a synergistic effect in the onset of stroke remains unclear. The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple inter-vertebral disk protrusion using a paired multivariate logistic regression method. Adjusting for known confounding variables including the patients’ age, gender, smoking status, alcohol consumption status, patient and family medical history, and clinical biochemical indices, elevated homocysteine level was related to the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal ho-mocysteine levels and blood lipids (odds ratio 1.409;95%confidence interval 1.127-1.761). These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids are predis-posed to stroke.
机标关键词：blood lipidsretrospective analysissynergistic effectsregression methodrisk factors
资助基金：This study was supported by a grant from Medical Science Data Sharing Network, Ministry of Science and Technology, China, (No.2005DKA32403, and Military Medical Scientific Research grants, No.11BJZ32, No.12BJZ271 and No.10BJZ202)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2923-2931 )
英文信息