Substance P and calcitonin gene-related peptide expression in dorsal root ganglia in sciatic nerve injury rats
Changma Fu
Zongsheng Yin
Defu Yu
Zuhua Yang
摘要：The neuropeptides, substance P and calcitonin gene-related peptide, have been shown to be involved in pain transmission and repair of sciatic nerve injury. A model of sciatic nerve defect was prepared by dissecting the sciatic nerve at the middle, left femur in female Sprague Dawley rats. The two ends of the nerve were encased in a silica gel tube. L5 dorsal root ganglia were harvested 7, 14 and 28 days post sciatic nerve injury for immunohistochemical staining. Results showed that substance P and cal-citonin gene-related peptide expression increased significantly in dorsal root ganglion of rats with sci-atic nerve injury. This increase peaked at 7 days, declined at 14 days, and reduced to normal levels by 28 days post injury. The findings indicate that the neuropeptides, substance P and calcitonin gene-related peptide, mainly increased in the early stages after sciatic nerve injury.
机标关键词：nerve injurysciatic nervesubstance Pimmunohistochemical stainingdorsal root gangliondorsal root gangliasilica gel
资助基金：This study was supported by the Major Program of Science and Technology of Ministry of Education, (No.207049)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 3124-3130 )
英文信息