Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis
Ling Fang
Qi Zheng
Tao Yang
Hui Zhao
Qiuxia Zhang
Kangning Li
Li Zhou
Haiyang Gong
Yongping Fan
Lei Wang
摘要：A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly cal ed Er-huang Formula) in combination with conventional therapy is an effective prescription for the treat-ment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis re-mains unclear. In this study, a MOG 35-55-immunized C57BL/6 mouse model of experimental au-toimmune encephalomyelitis was intragastrical y administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoim-mune encephalomyelitis was mediated by amelioration of axonal damage and promotion of rege-neration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.
机标关键词：multiple sclerosisprotein expressionclinical studymouse model
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81072765,81173237,81273742)Scientific Research Key Project of Beijing Municipal Commission of Education, (No. KZ201310025023)Special Fund for Capital Traditional Chinese Medicine and Nursing Research, (No.12ZYH01)
论文发表日期：2013-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 3306-3315 )
英文信息