Mechanism underlying the protective effect of Kaixin JieyuFang on vascular depression following cerebral white matter damage
Ying Zhang
Shijing Huang
Yanyun Wang
Junhua Pan
Jun Zheng
Xianhui Zhang
Yuxia Chen
Duojiao Li
摘要：The Chinese compound Kaixin Jieyu Fang can be used to treat vascular depression;however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin Jieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere-bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.
机标关键词：white matter damagemRNA expressioncerebral ischemiaBax proteinrat modelprotective effectcarotid arteries
资助基金：This study was supported by the National Natural Science Foundation of China, (No.30672696,81072801)the Natural Science Foundation of Beijing in China, (No.7093129)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 61-68 )
英文信息