Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints
Dongmei Duan
Xiuyan Yang
Ya Tu
Liping Chen
摘要：Preliminary basic research and clinical ifndings have demonstrated that electroacupuncture ther-apy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the single gene level;there are few reports regarding the mechanism at the whole-genome level. Using a rat genomic gene-chip, we proifled hippocampal gene expression changes in rats after electroacupuncture therapy. Electroacupuncture therapy alleviated depres-sion-related manifestations in the model rats. Using gene-chip analysis, we demonstrated that electroacupuncture at Baihui (DU20) and Yintang (EX-HN3) regulates the expression of 21 genes. Real-time PCR showed that the genes Vg f, Ig f2, Tmp32, Loc500373, Hif1a, Folr1, Nmb, and Rtn were upregulated or downregulated in depression and that their expression tended to nor-malize after electroacupuncture therapy. These results indicate that electroacupuncture at Baihui and Yintang modulates depression by regulating the expression of particular genes.
机标关键词：rat modelelectroacupuncture therapygene expressionbasic research
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81273847)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 76-83 )
英文信息