Resting-state connectivity in the default mode network and insula during experimental low back pain
Shanshan Zhang
Wen Wu
Guozhi Huang
Ziping Liu
Shigui Guo
Jianming Yang
Kangling Wang
摘要：Functional magnetic resonance imaging studies have shown that the insular cortex has a signif-icant role in pain identiifcation and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the default mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy sub-jects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the impor-tance of the interaction between these regions in pain processing.
机标关键词：magnetic resonance imaginganterior cingulate cortexinformation integrationhypertonic salinethe differenceslow back pain
资助基金：This study was supported by the Science and Technology Foundation of Guangdong Prov-ince of China, (No.2012B031800305)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 135-142 )