Acupuncture at Baihui and Dazhui reduces brain cell apoptosis in heroin readdicts
Xiaorong Hou
Rongjun Zhang
Hang Lv
Xinghui Cai
Guangchuan Xie
Xiaoge Song
摘要：Acupuncture at Baihui (GV20) and Dazhui (GV14) reduces neuronal loss and attenuates ultra-structural damage in cerebral ischemic rats. However, whether acupuncture can treat addiction and prevent readdiction through changes to brain cell ultrastructure remains unknown. In this study, cell apoptosis was observed in the hippocampus and frontal lobe of heroin readdicted rats by electron microscopy. Immunohistochemical staining displayed a reduction in Bcl-2 ex-pression and an increase in Bax expression in the hippocampus and frontal lobe. After rats were given acupuncture at Baihui and Dazhui, the pathological damage in the hippocampus and frontal lobe was signiifcantly reduced, Bcl-2 expression was upregulated and Bax expression was downregulated. Acupuncture exerted a similar effect with methadone, a commonly used drug for clinical treatment of drug addiction. Experimental ifndings suggest that acupuncture at Dazhui and Baihui can prevent brain cell apoptosis in heroin readdicted rats.
机标关键词：frontal lobecell apoptosiselectron microscopyclinical treatmentdrug addiction
资助基金：This study was financially sponsored by the Foundation for Excellent Young Talents in Uni-versities of Anhui Province in China, (No.2010SQRL105)the National Natural Science Foundation of China, (No.81173325)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 164-170 )
英文信息