Mild hypothermia for treatment of diffuse axonal injur y:a quantitative analysis of diffusion tensor imaging
Guojie Jing
Xiaoteng Yao
Yiyi Li
Yituan Xie
Wangan Li
Kejun Liu
Yingchao Jing
Baisheng Li
Yifan Lv
Baoxin Ma
摘要：Fractional anisotropy values in diffusion tensor imaging can quantitatively relfect the consistency of nerve ifbers after brain damage, where higher values generally indicate less damage to nerve ifbers. Therefore, we hypothesized that diffusion tensor imaging could be used to evaluate the effect of mild hypothermia on diffuse axonal injury. A total of 102 patients with diffuse axonal injury were randomly divided into two groups:normothermic and mild hypothermic treatment groups. Patient’s modiifed Rankin scale scores 2 months after mild hypothermia were signiifcant-ly lower than those for the normothermia group. The difference in average fractional anisotropy value for each region of interest before and after mild hypothermia was 1.32-1.36 times higher than the value in the normothermia group. Quantitative assessment of diffusion tensor imaging indicates that mild hypothermia therapy may be beneifcial for patients with diffuse axonal injury.
机标关键词：diffusion tensor imagingmild hypothermiadiffuse axonal injuryhypothermia therapyregion of interestthe consistencybrain damage
资助基金：This study was supported by the Natural Science Foundation of Guangdong Province in China, (No.10151600101000002)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 190-197 )
英文信息